Resolution of microsporidial sinusitis and keratoconjunctivitis by itraconazole treatment.
case_report · Level V
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Abstract
To report successful treatment of ocular infection caused by the microsporidium Encephalitozoon cuniculi in a person with acquired immunodeficiency syndrome (AIDS) and nasal and paranasal sinus infection. Case report. Microsporidial infection in a person with AIDS and with chronic sinusitis and keratoconjunctivitis was diagnosed by Weber modified trichrome stain and transmission electron microscopy. Symptoms completely resolved with itraconazole treatment (200 mg/day for 8 weeks) after albendazole therapy (400 mg/day for 6 weeks) was unsuccessful. Itraconazole can be recommended in ocular, nasal, and paranasal sinus infection caused by E. cuniculi parasites when treatment with albendazole fails.
Medical subject headings
- Antifungal Agents
- Encephalitozoon cuniculi
- Encephalitozoonosis
- Eye Infections, Parasitic
- Itraconazole
- Keratoconjunctivitis
- Sinusitis