Comparison of intraocular to plasma HIV-1 viral burden in patients with cytomegalovirus retinitis.
case_series · Level IV
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Abstract
To determine the relationship between plasma and intraocular human immunodeficiency virus-1 (HIV-1) viral loads in 12 consecutive patients undergoing ganciclovir implant surgery for cytomegalovirus (CMV) retinitis. Aqueous and vitreous specimens were assayed for HIV-1 viral load by polymerase chain reaction analysis (Roche Amplicor HIV Monitor; Roche Diagnostics Systems, Inc, Branchburg, New Jersey). It was possible to quantitatively assay HIV-1 burden in intraocular fluids using polymerase chain reaction analysis. In general, patients with plasma viral loads less than 250,000 copies/ml had undetectable (<200 copies/ml) HIV-1 in their aqueous and vitreous. It is likely that intraocular viral levels have several determinants in addition to plasma viral loads, with which they only partially correlate.
Medical subject headings
- AIDS-Related Opportunistic Infections
- Aqueous Humor
- Cytomegalovirus Retinitis
- HIV-1
- Viral Load
- Vitreous Body