p53 regulates a G2 checkpoint through cyclin B1.
basic_science · Level V
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- Record sourced from PubMed, PMID 10051609.
- Also identified by PMC identifier 26751.
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Abstract
The p53 tumor suppressor controls multiple cell cycle checkpoints regulating the mammalian response to DNA damage. To identify the mechanism by which p53 regulates G2, we have derived a human ovarian cell that undergoes p53-dependent G2 arrest at 32 degrees C. We have found that p53 prevents G2/M transition by decreasing intracellular levels of cyclin B1 protein and attenuating the activity of the cyclin B1 promoter. Cyclin B1 is the regulatory subunit of the cdc2 kinase and is a protein required for mitotic initiation. The ability of p53 to control mitotic initiation by regulating intracellular cyclin B1 levels suggests that the cyclin B-dependent G2 checkpoint has a role in preventing neoplastic transformation.
Medical subject headings
- Cell Cycle
- Cyclin B
- Tumor Suppressor Protein p53