Monospecific anti-GD1b IgG is required to induce rabbit ataxic neuropathy.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 10072058.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Of 22 rabbits sensitized with GD1b, 12 developed experimental sensory ataxic neuropathy. The affected rabbits had a higher level of serum IgG monospecific to GD1b than the unaffected ones. The GD1b-positive neuronal cytoplasms of rabbit dorsal root ganglia had larger diameters than the negative ones. IgG antibody monospecific to GD1b may preferentially bind to large primary sensory neurons, causing sensory ataxic neuropathy.
Medical subject headings
- Ataxia
- Gangliosides
- Immunoglobulin G