Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.
basic_science · Level V
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Abstract
Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of beta-catenin/Armadillo, which in turn activates gene transcription. Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of d-axin inhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Carrier Proteins
- Drosophila
- Drosophila Proteins
- Proteins
- Proto-Oncogene Proteins
- Repressor Proteins
- Signal Transduction
- Trans-Activators
- Transcription Factors