Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila.
basic_science · Level V
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Abstract
Segregation Distorter (SD) in Drosophila melanogaster is a naturally occurring meiotic drive system in which the SD chromosome is transmitted from SD/SD+ males in vast excess over its homolog owing to the induced dysfunction of SD+-bearing spermatids. The Sd locus is the key distorting gene responsible for this phenotype. A genomic fragment from the Sd region conferred full distorting activity when introduced into the appropriate genetic background by germline transformation. The only functional product encoded by this fragment is a truncated version of the RanGAP nuclear transport protein. These results demonstrate that this mutant RanGAP is the functional Sd product.
Medical subject headings
- Carrier Proteins
- Drosophila Proteins
- Drosophila melanogaster
- GTPase-Activating Proteins
- Genes, Insect
- Meiosis
- Nuclear Proteins