Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.
basic_science · Level V
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- Record sourced from PubMed, PMID 10077617.
- Also identified by PMC identifier 15875.
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Abstract
The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. Its expression in these leukemias is activated by chromosomal translocations and inversions at 14q32.1. Here we report the isolation and characterization of a new member of the TCL1 gene family, TCL1b, located approximately 16 kb centromeric of TCL1. The 1.2-kb TCL1b cDNA encodes a 14-kDa protein of 128 aa and shows 60% similarity to Tcl1. Expression profiles of TCL1 and TCL1b genes are very similar: both genes are expressed at very low levels in normal bone marrow and peripheral lymphocytes but are activated in T cell leukemia by rearrangements of the 14q32.1 region. Thus, translocations and inversions at 14q32. 1 in T cell malignancies involve two oncogenes.
Medical subject headings
- Chromosome Inversion
- Chromosomes, Human, Pair 14
- DNA-Binding Proteins
- Leukemia, T-Cell
- Oncogene Proteins
- Oncogenes
- Proto-Oncogene Proteins
- Transcription Factors
- Translocation, Genetic