The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors.
basic_science · Level V
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- Record sourced from PubMed, PMID 10097140.
- Also identified by PMC identifier 22397.
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Abstract
Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis. cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors.
Medical subject headings
- Chromosomes, Human, Pair 8
- DNA-Binding Proteins
- Genes, Tumor Suppressor
- Loss of Heterozygosity
- Neoplasms
- Transcription, Genetic
- Tumor Suppressor Proteins