Neurofilament protein levels in CSF are increased in dementia.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 10102440.
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Abstract
The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.
Medical subject headings
- Alzheimer Disease
- Dementia
- Neurofilament Proteins