Complexity in biological signaling systems.

Weng, G; Bhalla, U S; Iyengar, R · Science · 1999

basic_science · Level V

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Abstract

Biological signaling pathways interact with one another to form complex networks. Complexity arises from the large number of components, many with isoforms that have partially overlapping functions; from the connections among components; and from the spatial relationship between components. The origins of the complex behavior of signaling networks and analytical approaches to deal with the emergent complexity are discussed here.

Medical subject headings