Evidence for a polyclonal etiology of palmar fibromatosis.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 10194020.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
X chromosome inactivation patterns at the androgen receptor locus were evaluated to determine clonality in microdissected lesional tissue and in leukocytes from 2 women with Dupuytren's disease. The tissue from both patients generated a polyclonal pattern of X chromosome inactivation of the human androgen receptor gene. This finding supports a polyclonal reactive process as the underlying etiology for palmar fibromatosis.
Medical subject headings
- Dosage Compensation, Genetic
- Dupuytren Contracture
- Receptors, Androgen