Epstein-Barr virus-associated leiomyosarcoma of the thyroid in a child with congenital immunodeficiency: a case report.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 10199478.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We report an unusual case of multifocal leiomyosarcoma involving the thyroid gland, liver, and right lung in a child with congenital immunodeficiency disease. The smooth muscle nature of these neoplasms was confirmed by immunohistochemistry and electron microscopic studies. In situ hybridization showed large amounts of Epstein-Barr virus messenger RNA within the tumor cells. Although Epstein-Barr virus-associated smooth muscle tumors have been reported in children with AIDS and after organ transplantation, we are unaware of any case report in congenital immunodeficiency disease.
Medical subject headings
- Herpesviridae Infections
- Herpesvirus 4, Human
- Immunocompromised Host
- Immunologic Deficiency Syndromes
- Leiomyosarcoma
- Thyroid Neoplasms
- Tumor Virus Infections