New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.
review · Level V
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- Record sourced from PubMed, PMID 10200246.
- Also identified by PMC identifier 33561.
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Abstract
The most recently discovered PTEN tumor suppressor gene has been found to be defective in a large number of human cancers. In addition, germ-line mutations in PTEN result in the dominantly inherited disease Cowden syndrome, which is characterized by multiple hamartomas and a high proclivity for developing cancer. A series of publications over the past year now suggest a mechanism by which PTEN loss of function results in tumors. PTEN appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell growth and survival by dephosphorylating the 3 position of phosphoinositides.
Medical subject headings
- Genes, Tumor Suppressor
- Neoplasms
- Phosphatidylinositol 3-Kinases
- Phosphoric Monoester Hydrolases
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Tumor Suppressor Proteins