Biochemical alterations of uterine leiomyoma extracellular matrix in type IV Ehlers-Danlos syndrome.
case_series · Level IV
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Abstract
Collagens and glycosaminoglycans were assessed in 6 leiomyomas from otherwise healthy ("control") patients and 1 leiomyoma from a patient with type IV Ehlers-Danlos syndrome. The type IV Ehlers-Danlos leiomyoma contained less type III collagen and dermatan sulfate than control leiomyomas. This might contribute to the formation of a defective collagen network in type IV Ehlers-Danlos syndrome.
Medical subject headings
- Ehlers-Danlos Syndrome
- Extracellular Matrix
- Leiomyoma
- Uterine Neoplasms