Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 10205061.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Circadian rhythms of mammals are entrained by light to follow the daily solar cycle (photoentrainment). To determine whether retinal rods and cones are required for this response, the effects of light on the regulation of circadian wheel-running behavior were examined in mice lacking these photoreceptors. Mice without cones (cl) or without both rods and cones (rdta/cl) showed unattenuated phase-shifting responses to light. Removal of the eyes abolishes this behavior. Thus, neither rods nor cones are required for photoentrainment, and the murine eye contains additional photoreceptors that regulate the circadian clock.
Medical subject headings
- Biological Clocks
- Circadian Rhythm
- Light
- Ocular Physiological Phenomena
- Photoreceptor Cells, Vertebrate