Radiation therapy, cisplatin and hyperthermia in combination in management of patients with carcinomas of the head and neck with N2 or N3 metastatic cervical lymph nodes.
prospective_cohort · Level II
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Abstract
Fifty-three patients with carcinomas of the head and neck with N2 or N3 metastatic cervical lymph nodes were treated with radiation therapy (median, 70 Gy), cisplatin (median, 6 weekly courses) and hyperthermia (median, 6 twice weekly sessions). Local complete response was achieved in 82% and nodal complete response in 85% of patients. Overall survival was 51% and disease-free survival was 54% at 2 years. Toxicity was acceptable. Radiation therapy, cisplatin and hyperthermia in combination prove to be effective and safe in management of these patients.
Medical subject headings
- Antineoplastic Agents
- Carcinoma
- Cisplatin
- Cobalt Radioisotopes
- Head and Neck Neoplasms
- Hyperthermia, Induced
- Lymphatic Metastasis
- Radiopharmaceuticals