Platelet glycoprotein IIb/IIIa receptor antagonist used in conjunction with thrombolysis for peripheral arterial thrombosis.
case_series · Level IV
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- Record sourced from PubMed, PMID 10227513.
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Abstract
This feasibility study was designed to evaluate the therapeutic potential of intraarterial urokinase combined with abciximab, an IV platelet glycoprotein IIb/IIIa receptor antagonist, in peripheral arterial thrombosis. The administration of a highly potent glycoprotein IIb/IIIa inhibitor in conjunction with intraarterial fibrinolysis was safe in 14 patients. One distal embolization and no major bleeding occurred. The primary success rate was 100%. Treatment times ranged from 50 min to 8 hr. We found a reocclusion rate of 7% (1/14) at intermediate follow-up.
Medical subject headings
- Antibodies, Monoclonal
- Immunoglobulin Fab Fragments
- Plasminogen Activators
- Platelet Aggregation Inhibitors
- Thrombolytic Therapy
- Thrombosis
- Urokinase-Type Plasminogen Activator