Acute cholestatic hepatitis associated with pravastatin.
case_report · Level V
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- Record sourced from PubMed, PMID 10235223.
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Abstract
A 57-yr-old man presented with clinical and laboratory signs of acute cholestatic hepatitis. Symptoms had appeared 7 wk after he was started on pravastatin 20 mg/day for hypercholesterolemia. A full evaluation including ultrasound, computed tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic nonobstructive jaundice. The liver function abnormalities normalized 7 wk after cessation of therapy. Pravastatin should be considered as a potential cause of cholestatic hepatitis with favorable clinical outcome after drug withdrawal.
Medical subject headings
- Anticholesteremic Agents
- Chemical and Drug Induced Liver Injury
- Cholestasis
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Pravastatin