Correlation between rates of brain atrophy and cognitive decline in AD.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 10331700.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of serial scans. Rate of global cerebral volume loss correlated strongly with rate of change in Mini-Mental State Examination scores (r = 0.80, p < 0.001), implying clinical relevance to this marker of progression.
Medical subject headings
- Alzheimer Disease
- Brain
- Cognition Disorders