IgM antibody-related polyneuropathies: B-cell depletion chemotherapy using Rituximab.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 10331706.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Current treatments for anti-GM1 ganglioside or antimyelin-associated glycoprotein (anti-MAG) antibody-associated polyneuropathies are toxic or very costly. In this preliminary study the authors treated five patients with neuropathy and immunoglobulin M antibodies to GM1 ganglioside or MAG by depleting B cells using Rituximab--a monoclonal antibody directed against the B-cell surface membrane marker CD20. Within 3 to 6 months after treatment, all five patients had improved function, significantly increased quantitative strength measurements, and reduced titers of serum autoantibodies.
Medical subject headings
- Antibodies, Monoclonal
- Antineoplastic Agents
- B-Lymphocytes
- Immunoglobulin M
- Peripheral Nervous System Diseases