UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation.
basic_science · Level V
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- Record sourced from PubMed, PMID 10334995.
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Abstract
Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.
Medical subject headings
- Cell Membrane
- Escherichia coli Proteins
- Glycoconjugates
- Sialic Acids