Defective angiogenesis in mice lacking endoglin.
basic_science · Level V
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Abstract
Endoglin is a transforming growth factor-beta (TGF-beta) binding protein expressed on the surface of endothelial cells. Loss-of-function mutations in the human endoglin gene ENG cause hereditary hemorrhagic telangiectasia (HHT1), a disease characterized by vascular malformations. Here it is shown that by gestational day 11.5, mice lacking endoglin die from defective vascular development. However, in contrast to mice lacking TGF-beta, vasculogenesis was unaffected. Loss of endoglin caused poor vascular smooth muscle development and arrested endothelial remodeling. These results demonstrate that endoglin is essential for angiogenesis and suggest a pathogenic mechanism for HHT1.
Medical subject headings
- Blood Vessels
- Endothelium, Vascular
- Muscle, Smooth, Vascular
- Neovascularization, Physiologic
- Vascular Cell Adhesion Molecule-1