Adenocarcinoma of the colon with neuroendocrine features and secretory diarrhea.

Lew, E A; Lewin, K J; Zarchy, T; Pisegna, J R · Am J Gastroenterol · 1999

case_report · Level V

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Abstract

We report the case of a 63-yr-old man who had severe secretory diarrhea associated with colonic adenocarcinoma, with a prominent signet ring cell component and numerous endocrine cells as demonstrated by positive chromogranin-A staining. Improvement in the secretory diarrhea by the somatostatin analog Sandostatin suggested that the diarrhea was related to a functional neuroendocrine tumor within the colonic tumor, the first case to be reported in the literature.

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