Ibuprofen treatment versus gradual introduction of interferon beta-1b in patients with MS.
other · Level IV
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- Record sourced from PubMed, PMID 10371541.
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Abstract
Flu-like symptoms and injection site reactions are adverse effects of treatment with interferon beta-1b in patients with MS. We compared gradual dose escalation, ibuprofen treatment, or their combination in an open-label study. The combination reduced the incidence of flu-like symptoms to rates comparable with the placebo group in the pivotal trial but increased the frequency of injection site reactions, albeit modestly and transiently.
Medical subject headings
- Ibuprofen
- Interferon-beta
- Multiple Sclerosis