Recurrent multifocal demyelinating neuropathy with febrile illness and IgG subset deficiency.
case_series · Level IV
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Abstract
We describe a unique syndrome of recurrent multifocal demyelinating motor greater than sensory deficits in cranial and peripheral nerve distributions with rapid, spontaneous improvement. Three patients presented with episodes over a period of 7 to 24 years, largely accompanied by febrile illness. Variably decreased IgG1 and IgG3 subclass levels were found. We postulate an immune-mediated process based upon the clinical presentation and presence of decreased IgG subclass levels.
Medical subject headings
- Demyelinating Diseases
- Immunoglobulin G