Acanthamoeba keratitis with live isolates treated with cryosurgery and fluconazole.

Amoils, S P; Heney, C · Am J Ophthalmol · 1999

case_report · Level V

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Abstract

To report live, active trophozoites in an eye with Acanthamoeba keratitis that resembled Acanthamoeba polyphagia in the anterior chamber fluid obtained by transcorneal tap. After prediagnostic therapy had failed, we performed cryosurgery to break the corneal cell walls and treated the patient with oral fluconazole. The condition resolved after 8 weeks of oral fluconazole therapy. Residual leukoma was treated by corneal graft. Live, motile Acanthamoeba can be isolated from an anterior chamber tap; combination therapy with oral fluconazole after corneal cryosurgery may be effective.

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