Imaging and laboratory investigation in herpes simplex encephalitis.
case_report · Level V
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- Record sourced from PubMed, PMID 10407002.
- Also identified by PMC identifier 1736500.
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Abstract
A 14 day old baby presented with signs of an acute encephalitis. Clinically, herpes simplex encephalitis (HSE) was suspected. Early MRI and EEG were normal and there was rapid clinical improvement. A negative polymerase chain reaction (PCR) result on the initial CSF sample seemed to make HSE most unlikely. This diagnosis was subsequently proved after demonstration of specific antibody production using immunoelectrophoresis of the CSF. The child had extensive damage to brain tissue. The need for sequential analysis of CSF in making or refuting this diagnosis is illustrated.
Medical subject headings
- Encephalitis
- Herpes Simplex