Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH.
basic_science · Level V
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Abstract
A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right.
Medical subject headings
- Body Patterning
- Chick Embryo
- Embryonic Induction
- Embryonic and Fetal Development
- Fibroblast Growth Factors
- Nuclear Proteins
- Proteins
- Trans-Activators