Severe lactic acidosis induced by nucleoside analogues in an HIV-infected man.
case_report · Level V
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Abstract
Nucleoside analogues can induce myopathy or hepatitis by means of mitochondrial dysfunction. We report the case of a 31-year-old man infected with HIV who had a severe lactic acidosis without muscle or liver symptoms. He improved after hemodialysis and withdrawal of antiviral drugs. Muscle and liver evaluation allowed us to ascribe lactic acidosis to a mitochondriopathy induced by zidovudine and didanosine.
Medical subject headings
- Acidosis, Lactic
- Anti-HIV Agents
- Antimetabolites
- Didanosine
- Zidovudine