Embryonic stem cell-derived glial precursors: a source of myelinating transplants.
basic_science · Level V
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Abstract
Self-renewing, totipotent embryonic stem (ES) cells may provide a virtually unlimited donor source for transplantation. A protocol that permits the in vitro generation of precursors for oligodendrocytes and astrocytes from ES cells was devised. Transplantation in a rat model of a human myelin disease shows that these ES cell-derived precursors interact with host neurons and efficiently myelinate axons in brain and spinal cord. Thus, ES cells can serve as a valuable source of cell type-specific somatic precursors for neural transplantation.
Medical subject headings
- Astrocytes
- Diffuse Cerebral Sclerosis of Schilder
- Myelin Sheath
- Oligodendroglia
- Stem Cells