Neurodegenerative diseases of Guam: analysis of TAU.
basic_science · Level V
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Abstract
Mutations in the tau gene have been described in families affected by frontotemporal dementia with parkinsonism linked to chromosome 17. The authors performed a genetic and biochemical analysis of this gene and its product in the parkinsonism dementia complex of Guam, a disorder characterized by the extensive formation of neurofibrillary tangles. The tau gene is not a primary cause of the parkinsonism dementia complex of Guam.
Medical subject headings
- Chromosomes, Human, Pair 17
- Dementia
- Parkinson Disease
- tau Proteins