No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke.
case_control · Level III
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Abstract
Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke. We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.
Medical subject headings
- Brain Ischemia
- Cerebrovascular Disorders
- Nitric Oxide Synthase