Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops.
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- Record sourced from PubMed, PMID 10441593.
- Also identified by PMC identifier 1377993.
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Abstract
We apply the method of "blocking Gibbs" sampling to a problem of great importance and complexity-linkage analysis. Blocking Gibbs sampling combines exact local computations with Gibbs sampling, in a way that complements the strengths of both. The method is able to handle problems with very high complexity, such as linkage analysis in large pedigrees with many loops, a task that no other known method is able to handle. New developments of the method are outlined, and it is applied to a highly complex linkage problem in a human pedigree.
Medical subject headings
- Bayes Theorem
- Genetic Linkage
- Likelihood Functions
- Long QT Syndrome