Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 10446990.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region of pRb through its conserved region and to hypophosphorylated pRb. It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional regulation of genes involved in differentiation and tissue-specific expression.
Medical subject headings
- Chromosomes, Human, Pair 15
- DNA-Binding Proteins
- Drosophila Proteins
- Multigene Family
- Neoplasm Proteins
- Oncogenes
- Retinoblastoma Protein