Flagellar determinants of bacterial sensitivity to chi-phage.
basic_science · Level V
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- Record sourced from PubMed, PMID 10449785.
- Also identified by PMC identifier 22301.
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Abstract
Bacteriophage chi is known to infect motile strains of enteric bacteria by adsorbing randomly along the length of a flagellar filament and then injecting its DNA into the bacterial cell at the filament base. Here, we provide evidence for a "nut and bolt" model for translocation of phage along the filament: the tail fiber of chi fits the grooves formed by helical rows of flagellin monomers, and active flagellar rotation forces the phage to follow the grooves as a nut follows the threads of a bolt.
Medical subject headings
- Bacteriophages
- Escherichia coli
- Flagella
- Salmonella
- Serratia