Laryngeal aspergillosis following high dose inhaled fluticasone therapy for asthma.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 10456978.
- Also identified by PMC identifier 1745577.
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Abstract
The case history is presented of a 75 year old man with chronic asthma who was treated with inhaled fluticasone propionate in a daily dose of 2 mg using a Diskhaler. After three years of treatment he developed progressive hoarseness. Both vocal cords were colonised by Aspergillus fumigatus which formed a white slough on the surface. Biopsy specimens showed changes suggestive of laryngeal aspergillosis with an ulcerated epithelium, fibrinopurulent debris, and colonies of fungal hyphae. A slow recovery occurred after three months of treatment with topical amphotericin and with cessation of inhaled corticosteroids. Laryngoscopy is recommended if hoarseness occurs during treatment with fluticasone.
Medical subject headings
- Androstadienes
- Anti-Inflammatory Agents
- Aspergillosis
- Asthma
- Laryngeal Diseases