Long-term depression in hippocampal interneurons: joint requirement for pre- and postsynaptic events.
basic_science · Level V
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Abstract
Long-term depression (LTD) is a well-known form of synaptic plasticity of principal neurons in the mammalian brain. Whether such changes occur in interneurons is still controversial. CA3 hippocampal interneurons expressing Ca2+-permeable AMPA receptors exhibited LTD after tetanic stimulation of CA3 excitatory inputs. LTD was independent of NMDA receptors and required both Ca2+ influx through postsynaptic AMPA receptors and activation of presynaptic mGluR7-like receptors. These results point to the capability of interneurons to undergo plastic changes of synaptic strength through joint activation of pre- and postsynaptic glutamate receptors.
Medical subject headings
- Hippocampus
- Interneurons
- Neuronal Plasticity
- Receptors, AMPA
- Receptors, Metabotropic Glutamate
- Synapses