In-vivo demonstration of dopaminergic degeneration in dementia with Lewy bodies.

Walker, Z; Costa, D C; Ince, P; McKeith, I G; Katona, C L · Lancet · 1999

case_report · Level V

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Abstract

With the dopaminergic presynaptic ligand FP-CIT and single photon emission tomography we have shown a severe dopaminergic degeneration in a patient with a necropsy confirmed diagnosis of dementia with Lewy bodies (DLB). We suggest that functional imaging of the nigrostriatal dopamine pathway helps to distinguish DLB from Alzheimer's disease during life.

Medical subject headings