Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy.
case_control · Level III
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Abstract
Smoking and demographic variables are known to be risk factors for the development of thyroid-associated orbitopathy (TAO) among patients with Graves' hyperthyroidism, but a firm genetic basis for TAO has not been established. We show that the presence and severity of TAO are associated with an allele of the cytotoxic T lymphocyte antigen-4-gene.
Medical subject headings
- Antigens, Differentiation
- Genetic Predisposition to Disease
- Graves Disease
- Immunoconjugates
- Polymorphism, Genetic
- T-Lymphocytes, Cytotoxic