Induction of glomerular lesions in the kidneys of mice infected with vero toxin-producing Escherichia coli by lipopolysaccharide injection.
basic_science · Level V
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Abstract
Lipopolysaccharide was injected into germ-free mice after they had been infected with Vero toxin-producing Escherichia coli. Microscopic examination of the kidneys of these mice showed an increased number of mesangial cells and a vacancy in the glomerular capillary lumen. A significant elevation in the expression level of interferon (IFN)-gamma in the kidney may have played a key role in the induction of glomerular lesions, because the administration of neutralizing antibody to IFN-gamma markedly alleviated such lesions.
Medical subject headings
- Bacterial Toxins
- Escherichia coli
- Escherichia coli Infections
- Glomerular Mesangium
- Kidney Glomerulus
- Lipopolysaccharides