Are glomerular filtration rate estimations necessary before high dose methotrexate?
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 10490441.
- Also identified by PMC identifier 1718091.
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Abstract
Glomerular filtration rates (GFR) were estimated in 168 children (227 estimates) before treatment for haematological malignancies with high dose, intravenous methotrexate. Clinical management was altered on the basis of GFR in only two cases, both of whom had tumour lysis syndrome. Routine estimations of GFR do not contribute to management.
Medical subject headings
- Antimetabolites, Antineoplastic
- Glomerular Filtration Rate
- Methotrexate