High IL-18 (interferon-gamma inducing factor) concentration in a purine nucleoside phosphorylase deficient patient.
case_report · Level V
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- Record sourced from PubMed, PMID 10490534.
- Also identified by PMC identifier 1718032.
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Abstract
The plasma concentration of IL-18 (interferon-gamma inducing factor) was severely increased in a 3 year old boy with purine nucleoside phosphorylase (PNP) deficiency. The presence and activity of IL-18 were confirmed by immunoblotting and bioassay, respectively. These results suggest that IL-18 may be abundantly produced and secreted into plasma by PNP deficient macrophages in PNP deficiency.
Medical subject headings
- Interleukin-18
- Purine-Nucleoside Phosphorylase