HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus.
prospective_cohort · Level II
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Abstract
OBJECTIVE. To investigate the relation of HLA-DMA and DMB alleles to the development of systemic lupus erythematosus (SLE). We studied HLA-DMA and DMB alleles in 108 patients with SLE and 138 healthy controls using the amplification created restriction site method. The phenotypic frequency of HLA-DMA*0104 was significantly higher in patients with SLE than in healthy controls. The HLA-DMA and DMB alleles were not related to clinical manifestations and various laboratory tests in patients with SLE. HLA-DMA*0104 may be associated with the susceptibility of SLE.
Medical subject headings
- HLA-D Antigens
- Histocompatibility Antigens Class II
- Lupus Erythematosus, Systemic