Relevance of glutamate levels in the CSF of patients with HIV-1-associated dementia complex.
cross_sectional · Level IV
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Abstract
Chronic hyperactivation of excitatory amino acid pathways in the CNS of patients infected with HIV-1 may contribute to the pathogenesis of HIV-1-associated dementia complex. However, no correlation between the concentration of glutamate in CSF (mean 3.3 micromol/L) and either HIV-1 infection or HIV-1-associated dementia complex was observed. The results clarify several important issues regarding analysis of glutamate in the CSF and the role of excitotoxins in HIV-1-associated dementia complex.
Medical subject headings
- AIDS Dementia Complex
- Glutamic Acid
- HIV-1