Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells.
basic_science · Level V
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Abstract
We studied the effects of cyclosporine A (CsA) on the proliferation of LLC-PK1 proximal tubule epithelial cells. DNA damage was found to be an early event in CsA nephrotoxicity and could be a sensitive indicator of CsA injury in renal epithelial cells. Cell cycle arrest induced by CsA was coincident with elevated p53 levels. It is possible that trans-activating p21 may mediate the halting of the cell cycle through the CsA-induced accumulation of p53.
Medical subject headings
- Cell Death
- Cyclosporine
- Epithelial Cells
- Immunosuppressive Agents
- Kidney