Coordinated polar localization of auxin efflux carrier PIN1 by GNOM ARF GEF.

Steinmann, T; Geldner, N; Grebe, M; Mangold, S; Jackson, C L; Paris, S; Gälweiler, L; Palme, K et al. · Science · 1999

basic_science · Level V

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Abstract

The plant hormone auxin is transported in a polar manner along the shoot-root axis, which requires efflux carriers such as PIN1. Asymmetric localization of PIN1 develops from a random distribution in Arabidopsis early embryogenesis. Coordinated polar localization of PIN1 is defective in gnom embryos. GNOM is a membrane-associated guanine-nucleotide exchange factor on ADP-ribosylation factor G protein (ARF GEF). Thus, GNOM-dependent vesicle trafficking may establish cell polarity, resulting in polar auxin transport.

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