Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
case_report · Level V
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Abstract
Two patients with chloracne had concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of 144,000 and 26,000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years.
Medical subject headings
- Acne Vulgaris
- Dietary Fats
- Environmental Pollutants
- Fatty Acids
- Polychlorinated Dibenzodioxins
- Sucrose