Successful treatment of post-influenza pseudomembranous necrotising bronchial aspergillosis with liposomal amphotericin, inhaled amphotericin B, gamma interferon and GM-CSF.
case_report · Level V
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- Record sourced from PubMed, PMID 10525567.
- Also identified by PMC identifier 1745394.
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Abstract
A case of aspergillus tracheobronchitis following influenza A infection in an immunocompetent 35 year old woman is described that required prolonged mechanical ventilation for airways obstruction. Treatment included liposomal amphotericin, inhaled amphotericin, gamma interferon and GM-CSF. Liposomal amphotericin therapy was associated with reversible hepatosplenomegaly. Inhaled corticosteroids with continued antifungal therapy were used for the management of severe recurrent airway obstruction. After a prolonged course of treatment she survived with fixed airways obstruction unresponsive to corticosteroids.
Medical subject headings
- Amphotericin B
- Antifungal Agents
- Aspergillosis
- Aspergillus niger
- Bronchitis
- Interferon-gamma
- Tracheitis