Differences in lung bioavailability between different propellants for fluticasone propionate.
rct · Level II
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- Record sourced from PubMed, PMID 10533870.
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Abstract
The lung bioavailability (as adrenal suppression) of fluticasone propionate was about twofold greater with chlorofluorocarbons than hydrofluoroalkane as propellant. Direct switching between formulations on a microg equivalent may therefore be inadvisable.
Medical subject headings
- Aerosol Propellants
- Androstadienes
- Anti-Asthmatic Agents
- Chlorofluorocarbons
- Hydrocarbons, Fluorinated