Prion replication-once again blaming the dendritic cell.

Sy, M S; Gambetti, P · Nat Med · 1999

editorial · Level V

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Abstract

The lymphoid system is known to be involved in the propagation and spread of scrapie. However, the identity of the cell type responsible for scrapie replication remains controversial. A new study provides evidence that the follicular dendritic cells in the spleen are the targets of this infectious form of prion (pages 1308-1312).

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